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Estudio de fitoconstituyentes mediante docking molecular para el tratamiento de diabetes mellitus gestacional

Baron Restrepo, Jose Mateo (Escuela Colombiana de IngenieríaBogotáIngeniería Biomédica, 2022)

La diabetes mellitus gestacional (DMG) es una enfermedad grave del embrazo donde se presenta cualquier grado de intolerancia a la glucosa en el cuerpo, generando hiperglucemia en el cuerpo de las mujeres gestantes, ...
On Distributed Collaboration for Biomedical Analyses

Boujdad, Fatima-Zahra; Gaignard, Alban; Südholt, Mario; Garzón-Alfonso, Wilmer; Benavides Navarro, Luis Daniel; Redon, Richard (IEEE XploreLarnaca, Cyprus, 2019)

Cooperation of research groups is nowadays common for the development and execution of biomedical analyses. Multiple partners contribute data in this context, data that is often centralized for processing at some cluster-based ...
On Distributed Collaboration for Biomedical Analyses

Boujdad, Fatima-Zahra; Gaignard, Alban; Südholt, Mario; Garzón-Alfonso, Wilmer; Benavides Navarro, Luis Daniel; Redon, Richard (IEEE XploreLárnaca, Chipre., 2019)

Cooperation of research groups is nowadays common for the development and execution of biomedical analyses. Multiple partners contribute data in this context, data that is often centralized for processing at some cluster-based ...

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Estudio de fitoconstituyentes mediante docking molecular para el tratamiento de diabetes mellitus gestacional
...
Baron Restrepo, Jose Mateo | 2022

La diabetes mellitus gestacional (DMG) es una enfermedad grave del embrazo donde se presenta cualquier grado de intolerancia a la glucosa en el cuerpo, generando hiperglucemia en el cuerpo de las mujeres gestantes, ocasionando diferentes enfermedades sobre el feto, bebé y madre. En la actualidad existen tratamientos mediante insulina, gliburidad y metformina, pero cada uno de estos procedimientos presentan efectos secundarios sobre la paciente o sobre su bebé. Es por ello, que se busca encontrar una alternativa diferente a los compuestos para tratar la dibete mellitus gestacional. Por tanto, en esta tesis de grado se busca encontrar proteínas directamente relacionadas con la DMG, encontrar fitoconstituyentes que disminuyan la concentración de glucosa en sangre, encontrar sitios de unión en las proteínas encontradas y realizar docking molecular entre proteínas y fitoconstituyentes en los sitios de unión encontrados. Se encontró evidencia científica sobre la relación entre la DMG y las proteínas 4UV7-3Q4Z, además también se encontraron 72 fitoconstituyentes con características polares y apolares, los cuales fueron clasificados según su solubilidad. Con la proteína 4UV7 y fitoconstituyentes solubles se realizó docking molecular sobre sitios de unión obtenidos mediante software predictivos. Los resultados obtenidos con el docking molecular mostraron una afinidad electrónica muy similar entre los fitoconstituyentes-proteína y fármacos-proteína

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On Distributed Collaboration for Biomedical Analyses
...
Boujdad, Fatima-Zahra | 2019

Cooperation of research groups is nowadays common for the development and execution of biomedical analyses. Multiple partners contribute data in this context, data that is often centralized for processing at some cluster-based or supercomputer-based infrastructure. In contrast, real distributed collaboration that involves processing of data from several partners at different sites is rare. However, such distributed analyses are often very interesting, in particular, for scalability, security and privacy reasons. In this article, we motivate the need for real distributed biomedical analyses in the context of several ongoing projects, including the ICAN project that involves 34 French hospitals and affiliated research groups. We present a set of distributed architectures for such analyses that we have derived from discussions with different medical research groups and a study of related work. These architectures allow for scalability, security/privacy and reproducibility issues to be taken into account. Finally, we illustrate that these architectures can serve as the basis of a development method for biomedical distributed analyses.

LEER
On Distributed Collaboration for Biomedical Analyses
...
Boujdad, Fatima-Zahra | 2019

Cooperation of research groups is nowadays common for the development and execution of biomedical analyses. Multiple partners contribute data in this context, data that is often centralized for processing at some cluster-based or supercomputer-based infrastructure. In contrast, real distributed collaboration that involves processing of data from several partners at different sites is rare. However, such distributed analyses are often very interesting, in particular, for scalability, security and privacy reasons. In this article, we motivate the need for real distributed biomedical analyses in the context of several ongoing projects, including the ICAN project that involves 34 French hospitals and affiliated research groups. We present a set of distributed architectures for such analyses that we have derived from discussions with different medical research groups and a study of related work. These architectures allow for scalability, security/privacy and reproducibility issues to be taken into account. Finally, we illustrate that these architectures can serve as the basis of a development method for biomedical distributed analyses.

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Listar por tema "Bioinformática"

Estudio de fitoconstituyentes mediante docking molecular para el tratamiento de diabetes mellitus gestacional

On Distributed Collaboration for Biomedical Analyses

On Distributed Collaboration for Biomedical Analyses

Envíos recientes

Estudio de fitoconstituyentes mediante docking molecular para el tratamiento de diabetes mellitus gestacional

On Distributed Collaboration for Biomedical Analyses

On Distributed Collaboration for Biomedical Analyses

Listar por tema "Bioinformática"

Estudio de fitoconstituyentes mediante docking molecular para el tratamiento de diabetes mellitus gestacional ﻿

On Distributed Collaboration for Biomedical Analyses ﻿

On Distributed Collaboration for Biomedical Analyses ﻿

Envíos recientes

Estudio de fitoconstituyentes mediante docking molecular para el tratamiento de diabetes mellitus gestacional

On Distributed Collaboration for Biomedical Analyses

On Distributed Collaboration for Biomedical Analyses

Estudio de fitoconstituyentes mediante docking molecular para el tratamiento de diabetes mellitus gestacional

On Distributed Collaboration for Biomedical Analyses

On Distributed Collaboration for Biomedical Analyses